Natamycin (Pimaricin) is a polyene macrolide antibiotic produced by submerged aerobic fermentation of Streptomyces natalensis and related species,also known as Natamycine, Natamycina, Pimaricine, Pimaricina. Fermentation is conducted for several days, and the antibiotic is isolated either by broth extraction or by extraction of the mycelium.it is an antifungal which can be used as antibiotic to treat most fungus infections. Natamycin is an natural antimicrobial food additive used to protect food from mold and yeast growth. Its application is reliable and safe to human body. Natamycin has been globally used in a variety of foods and beverages, eg. Cheese , Baked food , Meat , Jam, Jelly, Marinated food, Fish, Chicken, Surface treatment for semi-dried, cured meat products , Drinks , Juice , Wines , Yogurts , man-made butter, Miscellaneous.. Natamycin is deemed to be a GRAS (Generally Recognized as Safe) substance in USA , and is assigned to be the number E-235-natural preservative in European Union.

Natamycin is a fungicide used to keep cheese from getting moldy. It works by making holes in the cell membranes of fungi, so their insides leak out. It is produced by Streptomyces natalensis bacteria. It is applied to cut slices of cheese by dipping or spraying. In grated cheese, a dry mixture is used, usually with cellulose to prevent caking. Natamycin belongs to preservatives.